Invited Talk: Deciphering Gene Regulatory Networks by in silico approaches
| Title | Invited Talk: Deciphering Gene Regulatory Networks by in silico approaches |
| Publication Type | Journal Articles |
| Year of Publication | 2006 |
| Authors | Hannenhalli S |
| Journal | 6th International Workshop on Data Mining in Bioinformatics (BIOKDD06)6th International Workshop on Data Mining in Bioinformatics (BIOKDD06) |
| Abstract | Biological processes are controlled at various levels in the celland while these mechanisms are poorly understood, tran- scriptional control is widely recognized as an important com- ponent and a better understanding of which will provide an efficient means for the therapeutic intervention in disease processes. We have been focusing on various computational problems pertaining to transcriptional regulation, namely, (1) representation and identification of transcription factor binding sites,(2) PolII promoter prediction,(3) Predicting interaction among transcription factors,(4) Transcriptional modeling, ie identifying arrangements of TFs that co- regulate a set of transcripts. I will present a brief overview of the computational approaches and challenges as well as a number of applications including transcriptional regulation in memory storage, heart failure, and osteoarthritis. |